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Secreted PCSK9 promotes LDL receptor degradation independently of proteolytic activity
PCSK9 (proprotein convertase subtilisin/kexin 9) is a secreted serine protease that regulates cholesterol homoeostasis by inducing post-translational degradation of hepatic LDL-R [LDL (low-density lipoprotein) receptor]. Intramolecular autocatalytic processing of the PCSK9 zymogen in the endoplasmic...
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| Main Authors: | , , , , , , , , , , , , |
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| Formáid: | Artigo |
| Teanga: | Inglês |
| Foilsithe: |
Portland Press Ltd.
2007
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| Ábhair: | |
| Rochtain Ar Líne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1948958/ https://ncbi.nlm.nih.gov/pubmed/17608623 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20070664 |
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