Secreted PCSK9 promotes LDL receptor degradation independently of proteolytic activity

PCSK9 (proprotein convertase subtilisin/kexin 9) is a secreted serine protease that regulates cholesterol homoeostasis by inducing post-translational degradation of hepatic LDL-R [LDL (low-density lipoprotein) receptor]. Intramolecular autocatalytic processing of the PCSK9 zymogen in the endoplasmic...

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Main Authors: Li, Jun, Tumanut, Christine, Gavigan, Julie-Ann, Huang, Waan-Jeng, Hampton, Eric N., Tumanut, Rachelle, Suen, Ka Fai, Trauger, John W., Spraggon, Glen, Lesley, Scott A., Liau, Gene, Yowe, David, Harris, Jennifer L.
Formáid: Artigo
Teanga:Inglês
Foilsithe: Portland Press Ltd. 2007
Ábhair:
Accelerated Publication
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC1948958/
https://ncbi.nlm.nih.gov/pubmed/17608623
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20070664
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