Oncogenic PIK3CA mutations occur in epidermal nevi and seborrheic keratoses with a characteristic mutation pattern

Activating mutations of the p110 α subunit of PI3K (PIK3CA) oncogene have been identified in a broad spectrum of malignant tumors. However, their role in benign or preneoplastic conditions is unknown. Activating FGF receptor 3 (FGFR3) mutations are common in benign skin lesions, either as embryonic...

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Autori principali: Hafner, Christian, López-Knowles, Elena, Luis, Nuno M., Toll, Agustí, Baselga, Eulàlia, Fernández-Casado, Alex, Hernández, Silvia, Ribé, Adriana, Mentzel, Thomas, Stoehr, Robert, Hofstaedter, Ferdinand, Landthaler, Michael, Vogt, Thomas, Pujol, Ramòn M., Hartmann, Arndt, Real, Francisco X.
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2007
Soggetti:
Biological Sciences
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC1948900/
https://ncbi.nlm.nih.gov/pubmed/17673550
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0705218104
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