Molecular purging of multiple myeloma cells by ex-vivo culture and retroviral transduction of mobilized-blood CD34(+ )cells

BACKGROUND: Tumor cell contamination of the apheresis in multiple myeloma is likely to affect disease-free and overall survival after autografting. OBJECTIVE: To purge myeloma aphereses from tumor contaminants with a novel culture-based purging method. METHODS: We cultured myeloma-positive CD34(+ )P...

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Main Authors: Deola, Sara, Scaramuzza, Samantha, Birolo, Roberto Sciarretta, Cergnul, Massimiliano, Ficara, Francesca, Dando, Jonathan, Voena, Claudia, Vai, Sergio, Monari, Marta, Pogliani, Enrico, Corneo, Gianmarco, Peccatori, Jacopo, Selleri, Silvia, Bordignon, Claudio, Roncarolo, Maria Grazia, Aiuti, Alessandro, Bregni, Marco
Formato: Artigo
Idioma:Inglês
Publicado: BioMed Central 2007
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Research
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC1948885/
https://ncbi.nlm.nih.gov/pubmed/17626627
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1479-5876-5-35
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