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Peroxynitrite decomposition catalysts: Therapeutics for peroxynitrite-mediated pathology

Inflamed tissue is often characterized by the production of NO and superoxide. These radicals react at diffusion-limited rates to form the powerful oxidant peroxynitrite (PN). When protonated, PN decomposes into either nitrate or reactive intermediates capable of mediating tissue damage by oxidation...

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Udgivet i:Proc Natl Acad Sci U S A
Principais autores: Salvemini, Daniela, Wang, Zhi-Qiang, Stern, Michael K., Currie, Mark G., Misko, Thomas P.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 1998
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC19452/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9482943/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.95.5.2659
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