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Founder mutations in BRCA1/2 are not frequent in Canadian Ashkenazi Jewish men with prostate cancer

BACKGROUND: Relatives of BRCA1 and BRCA2 mutation carriers have long been proposed by epidemiological studies to have an increased risk of developing prostate cancer. In the Ashkenazi Jewish (AJ) population, the existence of 3 frequent founder mutations, 185delAG and 5382insC in BRCA1 and 6174delT i...

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Udgivet i:BMC Med Genet
Principais autores: Hamel, Nancy, Kotar, Kimberley, Foulkes, William D
Format: Artigo
Sprog:Inglês
Udgivet: BMC 2003
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC194219/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12911837/
https://ncbi.nlm.nih.govhttps://doi.org/10.1186/1471-2350-4-7
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