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Endothelium-dependent metabolism by endocannabinoid hydrolases and cyclooxygenases limits vasorelaxation to anandamide and 2-arachidonoylglycerol

BACKGROUND AND PURPOSE: The endocannabinoids, N-arachidonoylethanolamide (anandamide) and 2-arachidonoylglycerol (2-AG) are rapidly degraded by fatty acid amide hydrolase (FAAH) and monoacylglycerol lipase (MGL). Whilst these lipid mediators are known to modulate vascular tone, the extent to which t...

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Detalhes bibliográficos
Main Authors: Ho, W-Sv, Randall, M D
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2007
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1942073/
https://ncbi.nlm.nih.gov/pubmed/17245358
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0707141
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