Classic Interleukin-6 Receptor Signaling and Interleukin-6 trans-Signaling Differentially Control Angiotensin II-Dependent Hypertension, Cardiac Signal Transducer and Activator of Transcription-3 Activation, and Vascular Hypertrophy in Vivo

Interleukin (IL)-6 acts via a receptor complex consisting of the cognate IL-6 receptor (IL-6R) or the soluble IL-6 receptor (sIL-6R) and glycoprotein 130 (gp130). Here, we investigated the role of these IL-6R components in hypertension and vascular hypertrophy in mice. Angiotensin (Ang) II (1.1 mg/k...

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Main Authors: Coles, Barbara, Fielding, Ceri A., Rose-John, Stefan, Scheller, Jürgen, Jones, Simon A., O’Donnell, Valerie B.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Investigative Pathology 2007
Assuntos:
Regular Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1941613/
https://ncbi.nlm.nih.gov/pubmed/17591976
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2353/ajpath.2007.061078
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