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A model-based optimization framework for the inference of regulatory interactions using time-course DNA microarray expression data

BACKGROUND: Proteins are the primary regulatory agents of transcription even though mRNA expression data alone, from systems like DNA microarrays, are widely used. In addition, the regulation process in genetic systems is inherently non-linear in nature, and most studies employ a time-course analysi...

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Autors principals: Thomas, Reuben, Paredes, Carlos J, Mehrotra, Sanjay, Hatzimanikatis, Vassily, Papoutsakis, Eleftherios T
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2007
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC1940027/
https://ncbi.nlm.nih.gov/pubmed/17603872
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2105-8-228
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