DNA Replication Stress Is a Determinant of Chronological Lifespan in Budding Yeast

The chronological lifespan of eukaryotic organisms is extended by the mutational inactivation of conserved growth-signaling pathways that regulate progression into and through the cell cycle. Here we show that in the budding yeast S. cerevisiae, these and other lifespan-extending conditions, includi...

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Main Authors: Weinberger, Martin, Feng, Li, Paul, Anita, Smith, Daniel L., Hontz, Robert D., Smith, Jeffrey S., Vujcic, Marija, Singh, Keshav K., Huberman, Joel A., Burhans, William C.
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2007
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC1939877/
https://ncbi.nlm.nih.gov/pubmed/17710147
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0000748
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