The reaction of fluorocitrate with aconitase and the crystal structure of the enzyme-inhibitor complex
It has been known for many years that fluoroacetate and fluorocitrate when metabolized are highly toxic, and that at least one effect of fluorocitrate is to inactivate aconitase. In this paper we present evidence supporting the hypothesis that the (−)-erythro diastereomer of 2-fluorocitrate acts as...
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| Publicado no: | Proc Natl Acad Sci U S A |
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| Principais autores: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
1996
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC19395/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8942997/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.93.24.13699 |
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