Design of helical, oligomeric HIV-1 fusion inhibitor peptides with potent activity against enfuvirtide-resistant virus

Enfuvirtide (ENF), the first approved fusion inhibitor (FI) for HIV, is a 36-aa peptide that acts by binding to the heptad repeat 1 (HR1) region of gp41 and preventing the interaction of the HR1 and HR2 domains, which is required for virus–cell fusion. Treatment-acquired resistance to ENF highlights...

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Autores principales: Dwyer, John J., Wilson, Karen L., Davison, Donna K., Freel, Stephanie A., Seedorff, Jennifer E., Wring, Stephen A., Tvermoes, Nicolai A., Matthews, Thomas J., Greenberg, Michael L., Delmedico, Mary K.
Formato: Artigo
Lenguaje:Inglês
Publicado: National Academy of Sciences 2007
Materias:
Biological Sciences
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC1937542/
https://ncbi.nlm.nih.gov/pubmed/17640899
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0701478104
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