An unusual cytokine:Ig-domain interaction revealed in the crystal structure of leukemia inhibitory factor (LIF) in complex with the LIF receptor

Leukemia inhibitory factor (LIF) receptor is a cell surface receptor that mediates the actions of LIF and other IL-6 type cytokines through the formation of high-affinity signaling complexes with gp130. Here we present the crystal structure of a complex of mouse LIF receptor with human LIF at 4.0 Å...

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Main Authors: Huyton, Trevor, Zhang, Jian-Guo, Luo, Cindy S., Lou, Mei-Zhen, Hilton, Douglas J., Nicola, Nicos A., Garrett, Thomas P. J.
Formáid: Artigo
Teanga:Inglês
Foilsithe: National Academy of Sciences 2007
Ábhair:
Biological Sciences
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC1937536/
https://ncbi.nlm.nih.gov/pubmed/17652170
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0705577104
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