CD81 on B cells promotes interleukin 4 secretion and antibody production during T helper type 2 immune responses

Mice lacking CD81 (TAPA-1), a widely expressed tetraspanin molecule, have impaired antibody responses to protein antigens. This defect is specific to antigens that preferentially stimulate a T helper 2 response (ovalbumin or keyhole limpet hemocyanin in alum) and is only seen with T cell-dependent a...

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Bibliografske podrobnosti
Main Authors: Maecker, Holden T., Do, Myoung-Sool, Levy, Shoshana
Format: Artigo
Jezik:Inglês
Izdano: The National Academy of Sciences 1998
Teme:
Biological Sciences
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC19373/
https://ncbi.nlm.nih.gov/pubmed/9482907
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