Protein Phosphatase 2A Dephosphorylation of Phosphoserine 112 Plays the Gatekeeper Role for BAD-Mediated Apoptosis

BAD, a proapoptotic molecule of the BCL2 family, is regulated by reversible phosphorylation. During survival, BAD is sequestered by 14-3-3 through serine 136 phosphorylation and is dissociated from BCL-X(L) through serine 155 phosphorylation. We report that phosphoserine 112 (pSer112) dephosphorylat...

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Detalhes bibliográficos
Main Authors: Chiang, Chi-Wu, Kanies, Cindy, Kim, Kwang Woon, Fang, Wei Bin, Parkhurst, Christina, Xie, Minhui, Henry, Travis, Yang, Elizabeth
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2003
Assuntos:
Cell Growth and Development
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC193703/
https://ncbi.nlm.nih.gov/pubmed/12944463
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.23.18.6350-6362.2003
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