Impaired osteoblastic differentiation, reduced bone formation, and severe osteoporosis in noggin-overexpressing mice

We describe the effects of the overexpression of noggin, a bone morphogenetic protein (BMP) inhibitor, on osteoblast differentiation and bone formation. Cells of the osteoblast and chondrocyte lineages, as well as bone marrow macrophages, showed intense β-gal histo- or cytostaining in adult noggin(+...

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Main Authors: Wu, Xue-Bin, Li, Yanan, Schneider, Adina, Yu, Wanqin, Rajendren, Gopalan, Iqbal, Jameel, Yamamoto, Matsuo, Alam, Mohammad, Brunet, Lisa J., Blair, Harry C., Zaidi, Mone, Abe, Etsuko
Formáid: Artigo
Teanga:Inglês
Foilsithe: American Society for Clinical Investigation 2003
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Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC193662/
https://ncbi.nlm.nih.gov/pubmed/12975477
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI200315543
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