Differential gene-expression patterns in genital fibroblasts of normal males and 46,XY females with androgen insensitivity syndrome: evidence for early programming involving the androgen receptor

BACKGROUND: Androgen insensitivity syndrome (AIS) comprises a range of phenotypes from male infertility to complete feminization. Most individuals with AIS carry germline mutations of the androgen receptor (AR) that interfere with or ablate its function. As genital fibroblasts retain expression of t...

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Main Authors: Holterhus, Paul-Martin, Hiort, Olaf, Demeter, Janos, Brown, Patrick O, Brooks, James D
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2003
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC193616/
https://ncbi.nlm.nih.gov/pubmed/12801411
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/gb-2003-4-6-r37
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