SR protein-mediated inhibition of CFTR exon 9 inclusion: molecular characterization of the intronic splicing silencer

The intronic splicing silencer (ISS) of CFTR exon 9 promotes exclusion of this exon from the mature mRNA. This negative influence has important consequences with regards to human pathologic events, as lack of exon 9 correlates well with the occurrence of monosymptomatic and full forms of CF disease....

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Bibliographic Details
Main Authors: Buratti, Emanuele, Stuani, Cristiana, De Prato, Greta, Baralle, Francisco E.
Format: Artigo
Language:Inglês
Published: Oxford University Press 2007
Subjects:
RNA
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1935002/
https://ncbi.nlm.nih.gov/pubmed/17576688
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkm444
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