Mechanisms by which common variants in the TCF7L2 gene increase risk of type 2 diabetes

Genetic variants in the gene encoding for transcription factor-7–like 2 (TCF7L2) have been associated with type 2 diabetes (T2D) and impaired β cell function, but the mechanisms have remained unknown. We therefore studied prospectively the ability of common variants in TCF7L2 to predict future T2D a...

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Detalhes bibliográficos
Main Authors: Lyssenko, Valeriya, Lupi, Roberto, Marchetti, Piero, Del Guerra, Silvia, Orho-Melander, Marju, Almgren, Peter, Sjögren, Marketa, Ling, Charlotte, Eriksson, Karl-Fredrik, Lethagen, υsa-Linda, Mancarella, Rita, Berglund, Göran, Tuomi, Tiinamaija, Nilsson, Peter, Del Prato, Stefano, Groop, Leif
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2007
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1934596/
https://ncbi.nlm.nih.gov/pubmed/17671651
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI30706
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