Regulated Degradation of the HIV-1 Vpu Protein through a βTrCP-Independent Pathway Limits the Release of Viral Particles

Viral protein U (Vpu) of HIV-1 has two known functions in replication of the virus: degradation of its cellular receptor CD4 and enhancement of viral particle release. Vpu binds CD4 and simultaneously recruits the βTrCP subunit of the SCF(βTrCP) ubiquitin ligase complex through its constitutively ph...

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Sparad:
Bibliografiska uppgifter
Huvudupphovsmän: Estrabaud, Emilie, Le Rouzic, Erwann, Lopez-Vergès, Sandra, Morel, Marina, Belaïdouni, Nadia, Benarous, Richard, Transy, Catherine, Berlioz-Torrent, Clarisse, Margottin-Goguet, Florence
Materialtyp: Artigo
Språk:Inglês
Publicerad: Public Library of Science 2007
Ämnen:
Research Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC1933454/
https://ncbi.nlm.nih.gov/pubmed/17676996
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.0030104
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