Regulated Degradation of the HIV-1 Vpu Protein through a βTrCP-Independent Pathway Limits the Release of Viral Particles

Viral protein U (Vpu) of HIV-1 has two known functions in replication of the virus: degradation of its cellular receptor CD4 and enhancement of viral particle release. Vpu binds CD4 and simultaneously recruits the βTrCP subunit of the SCF(βTrCP) ubiquitin ligase complex through its constitutively ph...

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Main Authors: Estrabaud, Emilie, Le Rouzic, Erwann, Lopez-Vergès, Sandra, Morel, Marina, Belaïdouni, Nadia, Benarous, Richard, Transy, Catherine, Berlioz-Torrent, Clarisse, Margottin-Goguet, Florence
Formato: Artigo
Idioma:Inglês
Publicado: Public Library of Science 2007
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Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC1933454/
https://ncbi.nlm.nih.gov/pubmed/17676996
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.0030104
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