Peptide-Mediated Interference with Influenza A Virus Polymerase

The assembly of the polymerase complex of influenza A virus from the three viral polymerase subunits PB1, PB2, and PA is required for viral RNA synthesis. We show that peptides which specifically bind to the protein-protein interaction domains in the subunits responsible for complex formation interf...

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Bibliographic Details
Main Authors: Ghanem, Alexander, Mayer, Daniel, Chase, Geoffrey, Tegge, Werner, Frank, Ronald, Kochs, Georg, García-Sastre, Adolfo, Schwemmle, Martin
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2007
Subjects:
Genome Replication and Regulation of Viral Gene Expression
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1933368/
https://ncbi.nlm.nih.gov/pubmed/17494067
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00724-07
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