A Genetic Screen for Mycobacterium tuberculosis Mutants Defective for Phagosome Maturation Arrest Identifies Components of the ESX-1 Secretion System

After phagocytosis, the intracellular pathogen Mycobacterium tuberculosis arrests the progression of the nascent phagosome into a phagolysosome, allowing for replication in a compartment that resembles early endosomes. To better understand the molecular mechanisms that govern phagosome maturation ar...

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Bibliographic Details
Main Authors: MacGurn, Jason A., Cox, Jeffery S.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2007
Subjects:
Cellular Microbiology: Pathogen-Host Cell Molecular Interactions
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1932882/
https://ncbi.nlm.nih.gov/pubmed/17353284
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.01872-06
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