SB-431542, a Transforming Growth Factor β Inhibitor, Impairs Trypanosoma cruzi Infection in Cardiomyocytes and Parasite Cycle Completion

The antiinflammatory cytokine transforming growth factor β (TGF-β) plays an important role in Chagas disease, a parasitic infection caused by the protozoan Trypanosoma cruzi. In the present study, we show that SB-431542, an inhibitor of the TGF-β type I receptor (ALK5), inhibits T. cruzi-induced act...

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Detalhes bibliográficos
Main Authors: Waghabi, Mariana C., Keramidas, Michelle, Calvet, Claudia M., Meuser, Marcos, Soeiro, Maria de Nazaré C., Mendonça-Lima, Leila, Araújo-Jorge, Tania C., Feige, Jean-Jacques, Bailly, Sabine
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2007
Assuntos:
Biologic Response Modifiers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1932517/
https://ncbi.nlm.nih.gov/pubmed/17526757
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00022-07
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