Interdomain Loop Mutation Asp190Cys of the Tetracycline Efflux Transporter TetA(B) Decreases Affinity for Substrate

Eitemau Tebyg

• Mutations in the tetA(B) gene that cause a change in substrate specificity of the tetracycline efflux pump.
  gan: Guay, G G, et al.
  Cyhoeddwyd: (1994)
• Susceptibility of Tetracyclines to Tet(A) Resistance Is Independent of Interdomain Loop Sequence
  gan: Fyfe, Corey, et al.
  Cyhoeddwyd: (2013)
• Glutamate residues located within putative transmembrane helices are essential for TetA(P)-mediated tetracycline efflux.
  gan: Kennan, R M, et al.
  Cyhoeddwyd: (1997)
• Fe(2+)-Tetracycline-Mediated Cleavage of the Tn10 Tetracycline Efflux Protein TetA Reveals a Substrate Binding Site near Glutamine 225 in Transmembrane Helix 7
  gan: McMurry, Laura M., et al.
  Cyhoeddwyd: (2002)
• Expression of the tetK gene from Staphylococcus aureus in Escherichia coli: comparison of substrate specificities of TetA(B), TetA(C), and TetK efflux proteins.
  gan: Guay, G G, et al.
  Cyhoeddwyd: (1993)