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Towards the uniform distribution of null P values on Affymetrix microarrays
Methods to control false-positive rates require that P values of genes that are not differentially expressed follow a uniform distribution. Commonly used microarray statistics can generate P values that do not meet this assumption. We show that poorly characterized variance, imperfect normalization,...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
BioMed Central
2007
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1929139/ https://ncbi.nlm.nih.gov/pubmed/17472745 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/gb-2007-8-5-r69 |
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