Structure-activity studies of dicationically substituted bis-benzimidazoles against Giardia lamblia: correlation of antigiardial activity with DNA binding affinity and giardial topoisomerase II inhibition.

Nine dicationically substituted bis-benzimidazoles were examined for their in vitro activities against Giardia lamblia WB (ATCC 30957). The potential mechanisms of action of these compounds were evaluated by investigating the relationship among in vitro antigiardial activity and the affinity of the...

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Pubblicato in:	Antimicrob Agents Chemother
Autori principali:	Bell, C A, Dykstra, C C, Naiman, N A, Cory, M, Fairley, T A, Tidwell, R R
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	American Society for Microbiology (ASM) 1993
Soggetti:	Research Article
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC192773/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8109934/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.37.12.2668
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