p53 Target Gene SMAR1 Is Dysregulated in Breast Cancer: Its Role in Cancer Cell Migration and Invasion

Tumor suppressor SMAR1 interacts and stabilizes p53 through phosphorylation at its serine-15 residue. We show that SMAR1 transcription is regulated by p53 through its response element present in the SMAR1 promoter. Upon Doxorubicin induced DNA damage, acetylated p53 is recruited on SMAR1 promoter th...

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Autores principales: Singh, Kamini, Mogare, Devraj, Giridharagopalan, Ramprasad Obula, Gogiraju, Rajinikanth, Pande, Gopal, Chattopadhyay, Samit
Formato: Artigo
Lenguaje:Inglês
Publicado: Public Library of Science 2007
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Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC1924604/
https://ncbi.nlm.nih.gov/pubmed/17668048
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0000660
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