Recombinant adeno-associated virus type 2 replication and packaging is entirely supported by a herpes simplex virus type 1 amplicon expressing Rep and Cap.

Recombinant adeno-associated virus (AAV) type 2 (rAAV) vectors have recently been shown to have great utility as gene transfer agents both in vitro and in vivo. One of the problems associated with the use of rAAV vectors has been the difficulty of large-scale vector production. Low-efficiency plasmi...

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Veröffentlicht in:	J Virol
Hauptverfasser:	Conway, J E, Zolotukhin, S, Muzyczka, N, Hayward, G S, Byrne, B J
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	American Society for Microbiology (ASM) 1997
Schlagworte:	Research Article
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC192344/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9343238/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.71.11.8780-8789.1997
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