An adenovirus-simian immunodeficiency virus env vaccine elicits humoral, cellular, and mucosal immune responses in rhesus macaques and decreases viral burden following vaginal challenge.

Six female rhesus macaques were immunized orally and intranasally at 0 weeks and intratracheally at 12 weeks with an adenovirus type 5 host range mutant (Ad5hr)-simian immunodeficiency virus SIVsm env recombinant and at 24 and 36 weeks with native SIVmac251 gp120 in Syntex adjuvant. Four macaques re...

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Vydáno v:	J Virol
Hlavní autoři:	Buge, S L, Richardson, E, Alipanah, S, Markham, P, Cheng, S, Kalyan, N, Miller, C J, Lubeck, M, Udem, S, Eldridge, J, Robert-Guroff, M
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	American Society for Microbiology (ASM) 1997
Témata:	Research Article
On-line přístup:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC192317/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9343211/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.71.11.8531-8541.1997
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An adenovirus-simian immunodeficiency virus env vaccine elicits humoral, cellular, and mucosal immune responses in rhesus macaques and decreases viral burden following vaginal challenge.

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