Effects of itraconazole on cytochrome P-450-dependent sterol 14 alpha-demethylation and reduction of 3-ketosteroids in Cryptococcus neoformans.

As in other pathogenic fungi, the major sterol synthesized by Cryptococcus neoformans var. neoformans is ergosterol. This yeast also shares with most pathogenic fungi a susceptibility of its cytochrome P-450-dependent ergosterol synthesis to nanomolar concentrations of itraconazole. Fifty percent in...

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Detalhes bibliográficos

Publicado no:	Antimicrob Agents Chemother
Principais autores:	Vanden Bossche, H, Marichal, P, Le Jeune, L, Coene, M C, Gorrens, J, Cools, W
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Microbiology (ASM) 1993
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC192235/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8257130/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.37.10.2101
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