MPTP and DSP-4 susceptibility of substantia nigra and locus coeruleus catecholaminergic neurons in mice is independent of parkin activity

Mutations in the parkin gene cause autosomal recessive familial Parkinson’s disease (PD). Parkin-deficient mouse models fail to recapitulate nigrostriatal dopaminergic neurodegeneration as seen in PD, but produce deficits in dopaminergic neurotransmission and noradrenergic-dependent behavior. Since...

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Main Authors: Thomas, Bobby, von Coelln, Rainer, Mandir, Allen S., Trinkaus, Daniel B., Farah, Mohamed H., Lim, Kah Leong, Calingasan, Noel Y., Beal, M. Flint, Dawson, Valina L., Dawson, Ted M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2007
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1920708/
https://ncbi.nlm.nih.gov/pubmed/17336077
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.nbd.2006.12.021
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