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THE ROLE OF ASCORBATE IN THE MODULATION OF HIF-1α PROTEIN AND HIF-DEPENDENT TRANSCRIPTION BY CHROMIUM(VI) AND NICKEL(II)
Molecular oxygen is involved in hydroxylation and subsequent degradation of HIF-1α, a subunit of HIF-1 transcription factor, therefore oxygen shortage (hypoxia) stabilizes this protein. However, HIF-1α can also be stabilized by transition metal ions in the presence of oxygen, suggesting that a diffe...
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| Autors principals: | , , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2007
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1920179/ https://ncbi.nlm.nih.gov/pubmed/17382205 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.freeradbiomed.2007.01.026 |
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