The UL84 protein of human cytomegalovirus acts as a transdominant inhibitor of immediate-early-mediated transactivation that is able to prevent viral replication.

The 86-kilodalton immediate-early (IE) 2 protein (IE2-p86) of human cytomegalovirus (HCMV) is a multifunctional regulator of HCMV gene expression which appears to be essential for triggering the lytic replicative cycle. IE2-p86 functions as a promiscuous transactivator of both viral and cellular gen...

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Pubblicato in:	J Virol
Autori principali:	Gebert, S, Schmolke, S, Sorg, G, Flöss, S, Plachter, B, Stamminger, T
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	American Society for Microbiology (ASM) 1997
Soggetti:	Research Article
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC191993/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9261435/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.71.9.7048-7060.1997
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