Identification and elimination of replication-competent adeno-associated virus (AAV) that can arise by nonhomologous recombination during AAV vector production.

Adeno-associated virus (AAV) vector preparations are often contaminated with variable amounts of replication-competent AAV (rcAAV), which may influence the behavior of these vectors both in cultured cells and in animals. A packaging plasmid/vector plasmid system containing no significant homology an...

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Vydáno v:	J Virol
Hlavní autoři:	Allen, J M, Debelak, D J, Reynolds, T C, Miller, A D
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	American Society for Microbiology (ASM) 1997
Témata:	Research Article
On-line přístup:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC191962/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9261406/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.71.9.6816-6822.1997
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