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The −11A of promoter DNA and two conserved amino acids in the melting region of σ(70) both directly affect the rate limiting step in formation of the stable RNA polymerase-promoter complex, but they do not necessarily interact

Formation of the stable, strand separated, ‘open’ complex between RNA polymerase and a promoter involves DNA melting of approximately 14 base pairs. The likely nucleation site is the highly conserved −11A base in the non-template strand of the −10 promoter region. Amino acid residues Y430 and W433 o...

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Detaylı Bibliyografya
Asıl Yazarlar: Schroeder, Lisa A., Choi, Ae-Jin, deHaseth, Pieter L.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Oxford University Press 2007
Konular:
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC1919498/
https://ncbi.nlm.nih.gov/pubmed/17567604
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkm431
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