A 437-base-pair deletion at the beginning of the latency-associated transcript promoter significantly reduced adrenergically induced herpes simplex virus type 1 ocular reactivation in latently infected rabbits.

In this study we used a herpes simplex virus type 1 (HSV-1) deletion mutant to identify a segment of the genome necessary for epinephrine-induced reactivation in the rabbit eye model of herpetic recurrent disease. In HSV-1 latently infected neural tissue, the only abundant viral products are the lat...

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הוצא לאור ב:	J Virol
Principais autores:	Hill, J M, Garza, H H, Su, Y H, Meegalla, R, Hanna, L A, Loutsch, J M, Thompson, H W, Varnell, E D, Bloom, D C, Block, T M
פורמט:	Artigo
שפה:	Inglês
יצא לאור:	American Society for Microbiology (ASM) 1997
נושאים:	Research Article
גישה מקוונת:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC191932/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9261376/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.71.9.6555-6559.1997
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