Attenuation of a human rotavirus vaccine candidate did not correlate with mutations in the NSP4 protein gene.

The NSP4 protein of a simian rotavirus was reported to induce diarrhea following inoculation of mice. If NSP4 is responsible for rotavirus diarrhea in humans, attenuation of a human rotavirus may be reflected in concomitant mutations in the NSP4 gene. After 33 passages in cultured monkey kidney cell...

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Bibliografische gegevens
Hoofdauteurs: Ward, R L, Mason, B B, Bernstein, D I, Sander, D S, Smith, V E, Zandle, G A, Rappaport, R S
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 1997
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Research Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC191897/
https://ncbi.nlm.nih.gov/pubmed/9223531
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