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Discovery of a human liver glycogen phosphorylase inhibitor that lowers blood glucose in vivo

An inhibitor of human liver glycogen phosphorylase a (HLGPa) has been identified and characterized in vitro and in vivo. This substance, [R-(R*,S*)]-5-chloro-N-[3-(dimethylamino)-2-hydroxy-3-oxo-1-(phenylmethyl)propyl]-1H-indole-2-carboxamide (CP-91149), inhibited HLGPa with an IC(50) of 0.13 μM in...

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Udgivet i:Proc Natl Acad Sci U S A
Principais autores: Martin, William H., Hoover, Dennis J., Armento, Sandra J., Stock, Ingrid A., McPherson, R. Kirk, Danley, Dennis E., Stevenson, Ralph W., Barrett, Eugene J., Treadway, Judith L.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 1998
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC19188/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9465093/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.95.4.1776
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