Two classes of human papillomavirus type 16 E1 mutants suggest pleiotropic conformational constraints affecting E1 multimerization, E2 interaction, and interaction with cellular proteins.

Random mutagenesis of human papillomavirus type 16 (HPV16) E1 was used to generate E1 missense mutants defective for interaction with either hUBC9 or 16E1-BP, two cDNAs encoding proteins that have been identified by their ability to interact with HPV16 E1 in two-hybrid assays. hUBC9, the human count...

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Pubblicato in:	J Virol
Autori principali:	Yasugi, T, Vidal, M, Sakai, H, Howley, P M, Benson, J D
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	American Society for Microbiology (ASM) 1997
Soggetti:	Research Article
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC191850/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9223484/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.71.8.5942-5951.1997
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