Human cytomegalovirus induces interleukin-8 production by a human monocytic cell line, THP-1, through acting concurrently on AP-1- and NF-kappaB-binding sites of the interleukin-8 gene.

Cytomegalovirus (CMV) infection induced interleukin-8 (IL-8) gene transcription in a human monocytic cell line, THP-1 cells, leading to IL-8 secretion. The functional analysis of the IL-8 gene revealed that both AP-1- and NF-kappaB factor-binding elements were involved in conferring the responsivene...

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Pubblicato in:	J Virol
Autori principali:	Murayama, T, Ohara, Y, Obuchi, M, Khabar, K S, Higashi, H, Mukaida, N, Matsushima, K
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	American Society for Microbiology (ASM) 1997
Soggetti:	Research Article
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC191819/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9188651/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.71.7.5692-5695.1997
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