Renal selective N-acetyl-gamma-glutamyl prodrugs: a study on the mechanism of activation of the renal vasodilator prodrug CGP 22979.

1. In this study the processes underlying the renal selectivity of the vasodilator prodrug CGP 22979 (N-acetyl-L-glutamic acid-N-[N2-(5-n-butyl-2-pyridyl) hydrazide]) were studied in rats. 2. The active drug CGP 18137 (2-hydrazino-5-n-butyl pyridine) selectively accumulated in the renal tissue follo...

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Detalhes bibliográficos
Main Authors: Drieman, J. C., Thijssen, H. H., Zeegers, H. H., Smits, J. F., Struyker Boudier, H. A.
Formato: Artigo
Idioma:Inglês
Publicado em: 1990
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1917514/
https://ncbi.nlm.nih.gov/pubmed/2331567
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