Expression of the poliovirus receptor in intestinal epithelial cells is not sufficient to permit poliovirus replication in the mouse gut.

Although the initial site of poliovirus replication in humans is the intestine, previously isolated transgenic mice which carry the human poliovirus receptor (PVR) gene (TgPVR mice), which develop poliomyelitis after intracerebral inoculation, are not susceptible to infection by the oral route. The...

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Veröffentlicht in:	J Virol
Hauptverfasser:	Zhang, S, Racaniello, V R
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	American Society for Microbiology (ASM) 1997
Schlagworte:	Research Article
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC191721/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9188553/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.71.7.4915-4920.1997
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