Antagonism of vasoconstriction induced by platelet-activating factor in guinea-pig perfused hearts by selective platelet-activating factor receptor antagonists.

Platelet-activating factor (Paf) is a potent coronary vasoconstrictor in rat, guinea-pig, dog and pig. The present study investigated the mechanism and duration of Paf in guinea-pig isolated, Krebs-perfused hearts. Dose-related and sustained decreases in cardiac contractility and increases in corona...

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Détails bibliographiques
Auteurs principaux: Piper, P. J., Stewart, A. G.
Format: Artigo
Langue:Inglês
Publié: 1987
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC1917207/
https://ncbi.nlm.nih.gov/pubmed/3034369
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