Novel and frequent mutations of hepatitis B virus coincide with a major histocompatibility complex class I-restricted T-cell epitope of the surface antigen.

We examined the full-length hepatitis B virus (HBV) envelope (surface antigen or HBV small surface antigen [HBsAg]) sequences of 12 different liver samples from 10 different hepatoma-containing chronic carriers. Surprisingly, novel and frequent mutations occurred predominantly at amino acids 40 and...

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Detalhes bibliográficos

Publicado no:	J Virol
Principais autores:	Tai, P C, Banik, D, Lin, G I, Pai, S, Pai, K, Lin, M H, Yuoh, G, Che, S, Hsu, S H, Chen, T C, Kuo, T T, Lee, C S, Yang, C S, Shih, C
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Microbiology (ASM) 1997
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC191713/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9151885/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.71.6.4852-4856.1997
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