Platelet desensitization induced by arachidonic acid is not due to cyclo-oxygenase inactivation and involves the endoperoxide receptor.

Human platelets pre-exposed to arachidonic acid (AA) (0.1-1 mM) or to the endoperoxide analogue U46619 (1-3 microM) and then washed and resuspended, failed to respond with aggregation or secretion to a second challenge by either agonist. The response to thrombin at low (0.04-0.1 u ml-1) but not at h...

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Detaylı Bibliyografya
Asıl Yazarlar: Carmo, L. G., Hatmi, M., Rotilio, D., Vargaftig, B. B.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 1985
Konular:
Research Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC1916664/
https://ncbi.nlm.nih.gov/pubmed/2994786
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