Nociceptin induced inhibition of K+ evoked glutamate release from rat cerebrocortical slices.

Nociceptin, an endogenous ligand for the orphan receptor ORL1, has recently been described. In this study we have shown that nociception inhibits 46 mM K(+)-stimulated glutamate release from rat perfused cerebrocortical slices with an IC50 of 51 nM. At 100 nM the inhibition amounted to 68 +/- 14% an...

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Bibliografiske detaljer
Main Authors: Nicol, B., Lambert, D. G., Rowbotham, D. J., Smart, D., McKnight, A. T.
Format: Artigo
Sprog:Inglês
Udgivet: 1996
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1915895/
https://ncbi.nlm.nih.gov/pubmed/8937708
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