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Deletion of nef slows but does not prevent CD4-positive T-cell depletion in human immunodeficiency virus type 1-infected human-PBL-SCID mice.

The pathogenicity of four human immunodeficiency virus type 1 (HIV-1) isolates with nef deleted for SCID mice repopulated with human peripheral blood leukocytes (hu-PBL-SCID mice) was studied. Deletion of nef led to a substantial reduction in CD4-positive T-cell depletion and delayed kinetics of pla...

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Udgivet i:J Virol
Principais autores: Gulizia, R J, Collman, R G, Levy, J A, Trono, D, Mosier, D E
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology (ASM) 1997
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC191576/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9094701/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.71.5.4161-4164.1997
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