Stimulation of the hypothalamo-pituitary-adrenal axis in the rat by the type 4 phosphodiesterase (PDE-4) inhibitor, denbufylline.

1. Preliminary studies in our laboratories showed that the synthetic xanthine analogue denbufylline, a selective type 4 phosphodiesterase (PDE-4) inhibitor, is a potent activator of the hypothalamo-pituitary-adrenal (HPA) axis when given orally to adult male rats. This paper describes the results of...

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Bibliographic Details
Main Authors:	Hadley, A. J., Kumari, M., Cover, P. O., Osborne, J., Poyser, R., Flack, J. D., Buckingham, J. C.
Format:	Artigo
Language:	Inglês
Published:	1996
Subjects:	Research Article
Online Access:	https://ncbi.nlm.nih.gov/pmc/articles/PMC1915710/ https://ncbi.nlm.nih.gov/pubmed/8894165
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Stimulation of the hypothalamo-pituitary-adrenal axis in the rat by the type 4 phosphodiesterase (PDE-4) inhibitor, denbufylline.

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