Herpesvirus saimiri encodes a functional homolog of the human bcl-2 oncogene.

Here we demonstrate that open reading frame 16 (ORF16) of the oncogenic herpesvirus saimiri protects cells from heterologous virus-induced apoptosis. The BH1 and BH2 homology domains are highly conserved in ORF16, and ORF16 heterodimerizes with Bcl-2 family members Bax and Bak. However, ORF16 lacks...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Nava, V E, Cheng, E H, Veliuona, M, Zou, S, Clem, R J, Mayer, M L, Hardwick, J M
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 1997
Pynciau:
Research Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC191568/
https://ncbi.nlm.nih.gov/pubmed/9094693
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