Immunization with a replication-deficient mutant of herpes simplex virus type 1 (HSV-1) induces a CD8+ cytotoxic T-lymphocyte response and confers a level of protection comparable to that of wild-type HSV-1.

Replication-deficient viruses provide an attractive alternative to conventional approaches used in the induction of antiviral immunity. We have quantitatively evaluated both the primary and memory cytotoxic T-lymphocyte (CTL) responses elicited by immunization with a replication-deficient mutant of...

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Pubblicato in:	J Virol
Autori principali:	Brehm, M A, Bonneau, R H, Knipe, D M, Tevethia, S S
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	American Society for Microbiology (ASM) 1997
Soggetti:	Research Article
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC191500/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9094625/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.71.5.3534-3544.1997
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